What is L-Carnosine found in Heaven Skincare New Prism Technology Creams?
At Skincare Organics we are looking at the active ingredient L-Carnosine (Prism Technology) found in Heaven Skincare Prism Age Defiance Cream & Prism Overnight Success Cream. In a Nut Shell – L-carnosine can help defy the visible signs of aging in the skin. It helps to maintain the skin’s elasticity, which can minimize wrinkles. It improves your overall skin condition and is able to treat tough leathery skin as well as help prevent many age signs on the face.
L-Carnosine, sometimes called simply Carnosine, is a combination of two amino acids, alanine and histidine. Remarkably these two amino acids work much more efficiently than they would have done if they hadn’t combined to form L-Carnosine in the first instance. While still combined, it has the unique ability to rejuvenate cells – to make old cells younger and extend their life-cycle. L-Carnosine is the only compound commercially available that possesses this very rare and unique ability.
Your body manufactures carnosine, found in high concentrations in skeletal muscle, the lenses of the eyes, the brain and the nervous system.
- Carnosine has been shown to protect human skin cells against UV radiation. Together with some other forms of radiation, UV causes mutations in DNA and protein damage that often lead to cancer. To combat this, use of DNA-protecting molecules in skin cosmetics like L-Carnosine is desirable. Carnosine falls among these molecules due to its antioxidant properties. In a study on human skin cells, carnosine was shown to reduce the oxidative damage caused by the UV on both DNA and proteins
- L- Carnosine acts as an anti-oxidant, a substance that neutralizes free radicals, which damage cells.
- L-Carnosine’s unique ability to repair cells, protect them and increase the effectiveness of so many other compounds within the body means that its effects are numerous and remarkable.
- Carnosine both supports life and protects from its destruction. It guards cells and protein tissues from oxidation damage. It prevents glycosylation – the process that produces AGEs to build up leading to collagen cross-linking, wrinkles and sags.
- Chronic glycolysis is speculated to accelerate aging, making carnosine a candidate for therapeutic potential.
Research studies in Australia confirm that L-Carnosine
“increases the longevity of fibroblast, the skin cells responsible for producing collagen”.
It also extends the Hayflick limi, the maximum number of times a cell can divide before dying—by an amazing 20%
In a study on human skin cells, L-carnosine was shown to reduce the oxidative damage caused by the UV on both DNA and proteins. It is also able to activate synthesis of other naturally produced antioxidants, such as glutathione peroxidase. Carnosine and related molecules have even stronger antioxidative capability than vitamin E . However, it is advisable to apply these two antioxidants together, not only for synergistic protective effects – vitamin E improves the delivery of carnosine, resulting in higher levels of this molecule in target tissue.
In the recent years, commercial sunscreen products started to include carnosine, and the benefits of it have been proven in studies of UV-irradiated skin. Compared to traditional sunscreens, carnosine-containing creams successfully prevented UV damage and resulted in a significantly better state of both DNA and protein (less oxidative damage) after the irradiation.
In a trial on volunteers with sensitive skin, carnosine showed a protective effect on skin barrier function (reduced water loss and perceived dryness after 28 days of usage). Biochemical experiments suggest that the cream achieved this by improving the skin and neural cell response to UV radiation.
L-Carnosine is also able to reduce the effects of glycation. This process occurs naturally during ageing and produces damaged forms of proteins, called advanced glycation end products (AGEs). Collagen is among the proteins most affected by this, and its glycation may be responsible for loss of elasticity or other negative consequences of skin ageing.
L-Carnosine is a competitive target for glycation, thus protecting valuable proteins from it. L-Carnosine improves skin visual parameters, maintains firmness, reduces roughness, fine lines and oily appearance.
Another major application of carnosine in skin care is wound healing. A preparation with carnosine was shown to promote collagen synthesis, cell proliferation and migration, which result in faster wound closure . Just like glycation protection, this benefit of carnosine is even more important for diabetes patients, as wound healing is impaired under this disease.
L-Carnosine, a protective, anti-ageing peptide?
L-Carnosine (beta-alanyl-L-histidine) has protective functions additional to anti-oxidant and free-radical scavenging roles. It extends cultured human fibroblast life-span, kills transformed cells, protects cells against aldehydes and an amyloid peptide fragment and inhibits, in vitro, protein glycation (formation of cross-links, carbonyl groups and AGEs) and DNA/protein cross-linking. L-Carnosine is an aldehyde scavenger, a likely lipofuscin (age pigment) precursor and possible modulator of diabetic complications, atherosclerosis and Alzheimer’s disease.